|  | Rune of Shadowstep Uncommon · Other | 40 | 1 | Other | | Uncommon | | |
| | Rune of Shadowflames Uncommon · Other | 40 | 1 | Other | | Uncommon | | |
| | Rune of Shadowbolts Uncommon · Other | 10 | 1 | Other | | Uncommon | | |
| | Rune of Shadow Specialization Uncommon · Other | 50 | | Other | | Uncommon | | |
| | Rune of Serpent Spread Uncommon · Other | 25 | 1 | Other | | Uncommon | | |
| | Rune of Sacrifice Uncommon · Other | 25 | 1 | Other | | Uncommon | | |
| | Rune of Sacred Shields Uncommon · Other | 40 | 1 | Other | | Uncommon | | |
| | Rune of Saber Slash Uncommon · Other | 10 | 1 | Other | | Uncommon | | |
| | Rune of Ruthless Precision Uncommon · Other | 40 | 1 | Other | | Uncommon | | |
| | Rune of Rolling Thunder Uncommon · Other | 50 | 1 | Other | | Uncommon | | |
| | Rune of Riptide Uncommon · Other | 50 | 1 | Other | | Uncommon | | |
| | Rune of Righteous Vengeance Uncommon · Other | 1 | 1 | Other | | Uncommon | | |
|  | Rune of Recall Uncommon · Quest | 60 | | Quest | | Uncommon | | |
|  | Rune of Recall Uncommon · Quest | 60 | | Quest | | Uncommon | | |
| | Rune of Rebuke Uncommon · Other | 1 | 1 | Other | | Uncommon | | |
| | Rune of Ranged Weapon Specialization Uncommon · Other | 50 | | Other | | Uncommon | | |
| | Rune of Raging Blow Uncommon · Other | 25 | 1 | Other | | Uncommon | | |
| | Rune of Quick Strike Uncommon · Other | 10 | 1 | Other | | Uncommon | | |
| | Rune of Quick Draw Uncommon · Other | 1 | 1 | Other | | Uncommon | | |
| | Rune of Purifying Power Uncommon · Other | 50 | 1 | Other | | Uncommon | | |
| | Rune of Primordial Fury Uncommon · Other | 25 | 1 | Other | | Uncommon | | |
| | Rune of Primal Energy Uncommon · Other | 50 | 1 | Other | | Uncommon | | |
| | Rune of Precision Uncommon · Other | 1 | 1 | Other | | Uncommon | | |
| | Rune of Power Uncommon · Other | 40 | 1 | Other | | Uncommon | | |
| | Rune of Potency Uncommon · Other | 50 | 1 | Other | | Uncommon | | |
| | Rune of Portals Common · Reagent | 40 | | Reagent | | Common | | 5 silver |
| | Rune of Pole Weapon Specialization Uncommon · Other | 50 | | Other | | Uncommon | | |
| | Rune of Piety Uncommon · Other | 40 | 1 | Other | | Uncommon | | |
| | Rune of Perfection Rare · Miscellaneous · Trinket | 25 | 20 | Miscellaneous | Trinket | Rare | | 50 silver |
| | Rune of Perfection Rare · Miscellaneous · Trinket | 45 | 40 | Miscellaneous | Trinket | Rare | | 1 gold |
| | Rune of Pandemic Uncommon · Other | 50 | 1 | Other | | Uncommon | | |
| | Rune of Overcharged Uncommon · Other | 50 | 1 | Other | | Uncommon | | |
|  | Rune of Opening Common · Quest | 1 | | Quest | | Common | | |
| | Rune of Nourishing Uncommon · Other | 40 | 1 | Other | | Uncommon | | |
|  | Rune of Nesting Common · Quest | 1 | | Quest | | Common | | |
| | Rune of Nature Specialization Uncommon · Other | 50 | | Other | | Uncommon | | |
| | Rune of Natural Potential Uncommon · Other | 1 | 1 | Other | | Uncommon | | |
| | Rune of Mutilation Uncommon · Other | 1 | | Other | | Uncommon | | |
| | Rune of Mutilation Uncommon · Other | 1 | 1 | Other | | Uncommon | | |
| | Rune of Metamorphosis Uncommon · Other | 25 | 1 | Other | | Uncommon | | |
| | Rune of Metamorphosis Epic · Miscellaneous · Trinket | 76 | 60 | Miscellaneous | Trinket | Epic | | 7 gold 20 silver 39 copper |
| | Rune of Mental Dexterity Uncommon · Other | 50 | 1 | Other | | Uncommon | | |
| | Rune of Mending Uncommon · Other | 1 | | Other | | Uncommon | | |
| | Rune of Meditation Specialization Uncommon · Other | 50 | | Other | | Uncommon | | |
| | Rune of Marksmanship Uncommon · Other | 1 | 1 | Other | | Uncommon | | |
| | Rune of Mark of Chaos Uncommon · Other | 60 | 1 | Other | | Uncommon | | |
| | Rune of Main Gauche Uncommon · Other | 25 | 1 | Other | | Uncommon | | |
| | Rune of Mace Specialization Uncommon · Other | 50 | | Other | | Uncommon | | |
| | Rune of Lone Wolf Uncommon · Other | 25 | 1 | Other | | Uncommon | | |
| | Rune of Light's Embrace Uncommon · Other | 40 | 1 | Other | | Uncommon | | |
